To make something from nothing: Ex Nihilo. No one can argue the God-like parallels in being a Creator. We are all endowed by our own creator inclinations, talents, strengths and weaknesses in making something of our lives with the hopes that in the end, we have left our mark - whether literally, as with the artist - or figuratively, in having re-created other versions of us.
The idea that an artist can leave this planet with everything she or he has within them having been said, does not seem possible. It would seem the body or the faculties may run themselves ragged before the Genie within our studio walls (Thank you, Elizabeth Gilbert) plays its final tacit note.
From nothing: Words.
From nothing: Beauty.
From nothing: Love.
From nothing: Something.